Harindranath Kadavath

Nov 20, 2024 | nature.com | Dhiman Ghosh |Matthias Schneider |Dzmitry Ashkinadze |Harindranath Kadavath |Peter Güntert |Georg Krainer | +4 more

AbstractThe complex kinetics of disease-related amyloid aggregation of proteins such as α-Synuclein (α-Syn) in Parkinson’s disease and Aβ42 in Alzheimer’s disease include primary nucleation, amyloid fibril elongation and secondary nucleation. The latter can be a key accelerator of the aggregation process. It has been demonstrated that the chaperone domain BRICHOS can interfere with the secondary nucleation process of Aβ42.