Harumi Hayakawa

Jun 14, 2023 | pubs.acs.org | Georgi Genov |Hiroki Takezawa |Makoto Fujita |Harumi Hayakawa

The tetradehydro-Diels–Alder (TDDA) reaction is a useful transformation for the rapid assembly of polycyclic scaffolds from simple linear precursors in a single synthetic step. However, the reaction requires careful substrate design and harsh reaction conditions to overcome the inherent entropic cost for this transformation. Herein we report an efficient site-selective TDDA transformation within a self-assembled Pd6L4 cage.