Hassan Jumaa
Sports Editor at Kenya Television Network
Sports Editor-Standard Group, KTN Sports Anchor, Producer & Host Zilizala Viwanjani SHOW, KTN News Monday_Friday 5PM_ 6PM, Panelist SOYA Awards,Member, K.E.G
Articles
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Aug 14, 2024 |
nature.com | Erika Tissino |Federico Pozzo |Francesca Rossi |Riccardo Bomben |Riccardo Moia |Giovanni D’Arena | +4 more
AbstractIn chronic lymphocytic leukemia (CLL), survival of neoplastic cells depends on microenvironmental signals at lymphoid sites where the crosstalk between the integrin VLA-4 (CD49d/CD29), expressed in ~40% of CLL, and the B-cell receptor (BCR) occurs. Here, BCR engagement inside–out activates VLA-4, thus enhancing VLA-4-mediated adhesion of CLL cells, which in turn obtain pro-survival signals from the surrounding microenvironment.
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