Heini M. Miettinen

Dec 27, 2023 | biorxiv.org | Vamseedhar Rayaprolu |Heini M. Miettinen |William Baker |Matthew Fisher

AbstractThe voltage sensing domain (VSD) is a four-helix modular protein domain that converts electrical signals into conformational changes, leading to open pores and active enzymes. In most voltage sensing proteins, the VSDs do not interact with one another and the S1-S3 helices are considered mainly as scaffolding. The two exceptions are the voltage sensing phosphatase (VSP) and the proton channel (Hv).