Heng Chang

1 month ago | biorxiv.org | Bocheng Wu |Heng Chang |Prashant Singh |Alexander Hostetler

AbstractThe TOX protein (thymocyte selection-associated high mobility group box) is a critical transcription factor implicated in both T acute lymphoblastic leukemia (T-ALL) and CD8+ T cell exhaustion. Gene perturbation studies suggest that inhibiting TOX may have therapeutic implications for both leukemia and T cell exhaustion. However, due to its complex molecular mechanisms and intrinsically disordered structure, TOX has not been effectively targeted by small molecules to date.

Nov 22, 2024 | nature.com | Shengyu Tao |Ruifei Ma |Guangyuan Ma |Heng Chang |Zheng Liang |Haocheng Ji | +5 more

AbstractRapid and accurate state of health (SOH) estimation of retired batteries is a crucial pretreatment for reuse and recycling. However, data-driven methods require exhaustive data curation under random SOH and state of charge (SOC) retirement conditions.