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Cerebrospinal fluid proteomics in patients with Alzheimer’s disease reveals five molecular subtypes with distinct genetic risk profiles - Nature Aging

Jan 8, 2024 | nature.com | Betty M. Tijms |Henne Holstege |Lisa Vermunt |Niccolò Tesi |Eugeen Vanmechelen |Frederik Barkhof | +1 more

AbstractAlzheimer’s disease (AD) is heterogenous at the molecular level. Understanding this heterogeneity is critical for AD drug development. Here we define AD molecular subtypes using mass spectrometry proteomics in cerebrospinal fluid, based on 1,058 proteins, with different levels in individuals with AD (n = 419) compared to controls (n = 187).
Author Correction: Common variants in Alzheimer’s disease and risk stratification by polygenic risk scores - Nature Communications

Feb 9, 2023 | nature.com | Itziar de Rojas |Najada Stringa |Anna Zettergren |Rebecca Sims |Céline Bellenguez |Miguel Calero | +79 more

Author notesThese authors contributed equally: Itziar de Rojas, Sonia Moreno-Grau, Niccolo Tesi, Benjamin Grenier-Boley, Victor Andrade, Iris E. Jansen. These authors jointly supervised this work: Jordi Clarimón, Mercè Boada, Wiesje M. van der Flier, Alfredo Ramirez, Jean-Charles Lambert, Sven J. van der Lee, Agustín Ruiz.

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