Henning Schmidt

2 weeks ago | bpspubs.onlinelibrary.wiley.com | Martin Johnson |Astra Zeneca Cambridge |Yu-Wei Lin |Henning Schmidt

AUCss area under the plasma concentration–time curve at steady-state CI confidence interval CLmetabolite/F clearance of metabolite (AZ5014) CLparent/F clearance of parent (osimertinib) C maxss maximum concentration at steady state C min pre-dose concentration C minss Cmin at steady state CYP cytochrome P450 EGFR epidermal growth factor receptor EGFRm EGFR mutation-positive IMP importance sampling ka absorption rate constant NSCLC non-small cell lung cancer OS overall survival PK...