Hidetaka Uryu

Jan 14, 2024 | nature.com | Koichi Takahashi |James Martin |Yu-Jung Tseng |Hidetaka Uryu

AbstractHematopoietic stem cells (HSCs) are capable of regenerating the blood system, but the instructive cues that direct HSCs to regenerate particular lineages lost to the injury remain elusive. Here, we show that iron is increasingly taken up by HSCs during anemia and induces erythroid gene expression and regeneration in a Tet2-dependent manner. Lineage tracing of HSCs reveals that HSCs respond to hemolytic anemia by increasing erythroid output.