Hidetoshi Igari

Nov 6, 2024 | nature.com | Kensuke Ishiguro |Yoko Kusuya |Kazuyuki Matsushita |Toshibumi Taniguchi |Hidetoshi Igari |Naruhiko Ishiwada | +11 more

AbstractStaphylococcus aureus can cause outbreaks and becomes multi-drug resistant through gene mutations and acquiring resistance genes. However, why S. aureus easily adapts to hospital environments, promoting resistance and recurrent infections, remains unknown. Here we show that a specific S. aureus lineage evolved from a clone that expresses the accessory gene regulator (Agr) system to subclones that reversibly suppressed Agr and caused an outbreak in the hospital setting. S.