Hinda Najem

Aug 21, 2024 | digitalcommons.library.tmc.edu | Hinda Najem |Spencer T. Lea |Shashwat Tripathi |Lisa Hurley

Home > UTHealth > GSBS > Journal Articles > 530 The Journal of Clinical Investigation Brain cancer, Cancer immunotherapy, Signal transduction, Immunology, Oncology DOWNLOADS Included in Allergy and Immunology Commons, Bioinformatics Commons, Biomedical Informatics Commons, Medical Sciences Commons, Oncology Commons COinS...

Jun 17, 2024 | jci.org | Hinda Najem |Shashwat Tripathi |Lisa Hurley |Spencer T. Lea

AbstractSTING agonists can reprogram the tumor microenvironment to induce immunological clearance within the central nervous system. Using multiplexed sequential immunofluorescence (SeqIF) and the Ivy Glioblastoma Atlas, STING expression was found in myeloid populations and in the perivascular space. The STING agonist 8803 increased median survival in multiple preclinical models of glioblastoma, including QPP8, an immune checkpoint blockade–resistant model, where 100% of mice were cured.