Ho-Chung Chen

1 month ago | biorxiv.org | Ho-Chung Chen |Hsing Hui Wang |Karl B. Shpargel |Lisa Kohn

AbstractType 1 Diabetes Mellitus (T1D) is driven by chronic autoimmune destruction of pancreatic beta cells, primarily mediated by CD8+ progenitor T cells that replenish pathogenic effectors. However, the regulatory mechanisms guiding this progenitor-to-effector transition remain unclear. T1D susceptibility has been linked to an X chromosome region (Xp13-p11) containing UTX, an epigenetic regulator.