Holly A. Gamlen

Mar 15, 2023 | nature.com | Daniela V. Wenge |Homa Rahnamoun |Richard Stone |Wenbin Xiao |Holly A. Gamlen |Aaron J. Stonestrom | +6 more

AbstractChromatin-binding proteins are critical regulators of cell state in haematopoiesis1,2. Acute leukaemias driven by rearrangement of the mixed lineage leukaemia 1 gene (KMT2Ar) or mutation of the nucleophosmin gene (NPM1) require the chromatin adapter protein menin, encoded by the MEN1 gene, to sustain aberrant leukaemogenic gene expression programs3,4,5.