Holly S Hajare

Oct 3, 2024 | biorxiv.org | Sandra Zakrzewska |Samantha Nixon |Zhou Chen |Holly S Hajare

AbstractDinoflagellates and cyanobacteria in harmful 'red tide' algal blooms produce saxitoxin (STX) and ~50 congeners that block voltage gated sodium channel (NaV) function and disrupt bioelectrical signals1-4. Consuming seafood carrying these lethal toxins causes paralytic shellfish poisoning (PSP), a growing public health hazard due to climate change5-7 that motivates efforts to detect these toxins and counteract their noxious effects.