Iain Chalmers

Oxford

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Articles

The differences and overlaps between ‘explanatory’ and ‘pragmatic’ controlled trials: a historical perspective

Nov 22, 2023 | journals.sagepub.com | Paul Glasziou |Robert Matthews |Isabelle Boutron |Iain Chalmers

In designing a controlled trial, a potential tension may exist between (1) providing insights into therapeutic mechanisms and (2) guiding decisions about ‘what works’ in everyday practice.

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