Iakovos Lazaridis

Jun 22, 2023 | nature.com | János Fuzik |Pierre Le Merre |Felix Jung |Antonio Lentini |Moritz Weglage |Iakovos Lazaridis | +4 more

AbstractExcitatory projections from the lateral hypothalamic area (LHA) to the lateral habenula (LHb) drive aversive responses. We used patch-sequencing (Patch-seq) guided multimodal classification to define the structural and functional heterogeneity of the LHA–LHb pathway. Our classification identified six glutamatergic neuron types with unique electrophysiological properties, molecular profiles and projection patterns.