Ignas Gaska

Jul 6, 2023 | nature.com | Ignas Gaska |Shashank Shekhar

AbstractCells control actin assembly by regulating reactions at actin filament barbed ends. Formins accelerate elongation, capping protein (CP) arrests growth and twinfilin promotes depolymerization at barbed ends. How these distinct activities get integrated within a shared cytoplasm is unclear. Using microfluidics-assisted TIRF microscopy, we find that formin, CP and twinfilin can simultaneously bind filament barbed ends.

Apr 26, 2023 | biorxiv.org | Heidi Ulrichs |Ignas Gaska |Shashank Shekhar

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