Immunology Programme

Aug 16, 2023 | cell.com | Isabella Ferreira |Colin Lee |William Foster |Immunology Programme

Highlights • Two doses AZD1222 and BNT162b2 dose 3 show lower neutralization in older individuals • Reduced neutralization is not related to binding antibody or spike-specific B cell frequency • Reduced neutralization associates with circulating “atypical” B cells in the elderly • T cell responses, especially IL-2 secretion, show age-associated impairment post dose 3 Summary Suboptimal responses to a primary vaccination course have been reported in the elderly, but there is little information...