Insuk Lee

Dec 27, 2024 | nature.com | Insuk Lee

AbstractImmune checkpoint blockade (ICB) has become a standard anti-cancer treatment, offering durable clinical benefits. However, the limited response rate of ICB necessitates biomarkers to predict and modulate the efficacy of the therapy. The gut microbiome’s influence on ICB efficacy is of particular interest due to its modifiability through various interventions. However, gut microbiome biomarkers for ICB response have been inconsistent across different studies.

Aug 27, 2024 | nature.com | Daniel Chang |Insuk Lee |Vanessa L Kronzer |Levi Teigen

AbstractRecent advancements in translational gut microbiome research have revealed its crucial role in shaping predictive healthcare applications. Herein, we introduce the Gut Microbiome Wellness Index 2 (GMWI2), an enhanced version of our original GMWI prototype, designed as a standardized disease-agnostic health status indicator based on gut microbiome taxonomic profiles.

Feb 27, 2024 | nature.com | Wei Gordon |Seungbyn Baek |Sarah L. Fong |Alex Galazyuk |Insuk Lee |Nancy B. Simmons | +4 more

Correction to: Nature Communications https://doi.org/10.1038/s41467-023-44186-y, published online 09 January 2024The original version of this Article contained an error in Fig. 6. In the original version of Fig. 6, the arrow under “gene expression” for big brown bat “urine-concentration” was red and pointing down when it should have been green and pointing up. This has been corrected in both the PDF and HTML versions of the Article.

Jan 9, 2024 | nature.com | Wei Gordon |Seungbyn Baek |Sarah L. Fong |Alex Galazyuk |Insuk Lee |Nancy B. Simmons | +4 more

AbstractFrugivory evolved multiple times in mammals, including bats. However, the cellular and molecular components driving it remain largely unknown.