Integrative Biosciences

Sep 25, 2023 | onlinelibrary.wiley.com | Sean T Bresnahan |Huck Institutes |Integrative Biosciences |David Galbraith

1 INTRODUCTION Phenotypic variation is essential for evolution—it is the raw material on which natural selection acts (Allendorf et al., 2022)—and has been demonstrated for numerous traits, including behaviour in animals (Foster & Sih, 2013). Behaviours are among the most plastic of phenotypes, and individuals from the same population often vary substantially and consistently in their behavioural responses to the same stimuli (Laskowski et al., 2022).

Jul 28, 2023 | jneuroinflammation.biomedcentral.com | Integrative Biosciences

Identification of the mechanisms whereby systemic inflammation leads to neuroinflammation [49] is an area of research with exceptionally high translational impact. The main finding of the present work is that intraperitoneally applied LPS causes a surprisingly fast and well-defined switch in hippocampal and neocortical state, with an onset in around 10 min after the injection. This effect was robust and showed little inter-individual variation.