Irene Beusch

Apr 18, 2024 | cell.com | Irene Beusch

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Nov 6, 2023 | nature.com | Antoine Cléry |Stefan Gerhardy |Katharina M. Betz |Jarosław Mazur |Irene Beusch |Mark Robinson | +1 more

AbstractThe conserved SR-like protein Npl3 promotes splicing of diverse pre-mRNAs. However, the RNA sequence(s) recognized by the RNA Recognition Motifs (RRM1 & RRM2) of Npl3 during the splicing reaction remain elusive. Here, we developed a split-iCRAC approach in yeast to uncover the consensus sequence bound to each RRM. High-resolution NMR structures show that RRM2 recognizes a 5´-GNGG-3´ motif leading to an unusual mille-feuille topology.

Jul 20, 2023 | cell.com | Irene Beusch |Hiten D. Madhani

First author Irene Beusch and corresponding author Hiten Madhani share with us some of their first-hand experiences with conducting science and some behind-the-scenes details about their paper, “Targeted high throughput mutagenesis of the human spliceosome reveals its in vivo operating principles.”Main textWhat was your path to becoming a scientist, and can you tell us a bit about your current role? IB: I grew up in a town close to Zurich, Switzerland.