Irene Görzer

Mar 30, 2023 | biorxiv.org | Elisabeth Puchhammer-Stöckl |Irene Görzer |Madlen Mollik |Lukas Eisler

AbstractCell entry is a crucial step for a virus to infect a host cell. Human cytomegalovirus (HCMV) utilizes the glycoprotein B (gB) to fuse the viral and host cell membrane upon receptor binding of gH/gL-containing complexes. Fusion is mediated by major conformational changes of gB from a metastable pre-fusion to a stable post-fusion whereby the central trimeric coiled-coils, formed by domain (D) III α helices, remain structurally nearly unchanged.