J. Luis Espinoza

Sep 21, 2024 | mdpi.com | Lâm Vũ |J. Luis Espinoza |Shohei Mizuno |Akiyoshi Takami

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Nov 30, 2023 | frontiersin.org | J. Luis Espinoza |Shohei Mizuno

1 IntroductionSince its identification in 1979 and the revelation of its role as a tumor suppressor gene in 1989, tumor protein 53 (TP53) has been a hot topic in the field of cancer research (1). TP53 is the most frequently mutated gene in cancer (2, 3). The frequency of TP53 mutations is highly variable among the different types and stages of cancers (4).