Jack R. Suggs

Aug 7, 2024 | nature.com | Laura Maiorino |Yiming Zhang |Jack R. Suggs

AbstractSystemically administered cytokines are potent immunotherapeutics but can cause severe dose-limiting toxicities. To overcome this challenge, cytokines have been engineered for intratumoral retention after local delivery. However, despite inducing regression of treated lesions, tumor-localized cytokines often elicit only modest responses at distal untreated tumors.