Jacob Ellegood

Dec 4, 2024 | nature.com | Hyosang Kim |Hyun Kim |Jacob Ellegood |Jin Kim

AbstractDyrk1A deficiency is linked to various neurodevelopmental disorders, including developmental delays, intellectual disability (ID) and autism spectrum disorders (ASD). Haploinsufficiency of Dyrk1a in mice reportedly leads to ASD-related phenotypes. However, the key pathological mechanisms remain unclear and human DYRK1A mutations remain uncharacterized in mice. Here, we generated and studied Dyrk1a-knockin mice carrying a human ASD patient mutation (Ile48LysfsX2; Dyrk1a-I48K mice).

Nov 5, 2024 | biorxiv.org | Linh Pham |Linh Phạm |Elisa Guma |Jacob Ellegood |Jason Lerch

AbstractStructural covariance in brain anatomy is thought to reflect inter-regional sharing of developmental influences - although this hypothesis has proved hard to causally test. Here, we use neuroimaging in humans and mice to study sex-differences in anatomical covariance - asking if regions that have developed shared sex differences in volume across species also show shared sex difference in volume covariance.