Jaimena H. Wheel

Jun 21, 2024 | biorxiv.org | D. Leonardo Garcia-Ramirez |Jenna McGrath |Ngoc Hà |Ngọc Hà |Jaimena H. Wheel

AbstractSpinal circuitry produces the rhythm and patterning of locomotion. However, both descending and sensory inputs are required to initiate and adapt locomotion to the environment. Spinal cord injury (SCI) disrupts descending controls of the spinal cord, producing paralysis. Epidural stimulation (ES) is a promising clinical therapy for motor control recovery and is capable of reactivating the lumbar spinal locomotor networks, yet little is known about the effects of ES on locomotor neurons.