Jakub Scaber

Jun 13, 2024 | cell.com | Jakub Scaber |Alex Clark |Yinyan Xu |Iona Thomas-Wright

Highlights • iPSC motor (MN) & sensory neurons (SN) allow studying selective vulnerability in ALS • The iPSC model partly reproduced differential expression between adult MN & SN • C9ORF72 RNA foci, dipeptides & axonal transport slowing were seen in iPSC MN & SN • These phenotypes unlikely explain the cell-type selectivity of ALS in isolation Summary Induced pluripotent stem cell (iPSC)-derived motor neurons (MNs) from patients with amyotrophic lateral sclerosis (ALS) and the C9ORF72...