James B Reinecke

Sep 13, 2024 | biorxiv.org | James B Reinecke |Leyre Jimenez Garcia |Amy Gross |Maren Cam

AbstractPurpose:Lung metastasis is responsible for nearly all deaths caused by osteosarcoma, the most common pediatric bone tumor. How malignant bone cells coerce the lung microenvironment to support metastatic growth is unclear. The purpose of this study is to identify metastasis-specific therapeutic vulnerabilities by delineating the cellular and molecular mechanisms underlying osteosarcoma lung metastatic niche formation.

Jun 10, 2024 | biorxiv.org | James B Reinecke |Amanda Saraf |John Hinckley |Amy Gross

AbstractOsteosarcoma is an aggressive and deadly bone tumor, primarily afflicting children, adolescents, and young adults. Poor outcomes for osteosarcoma patients are intricately linked with the development of lung metastasis.

Jan 12, 2024 | biorxiv.org | Amy Gross |James B Reinecke |Maren Cam |Leyre Jimenez Garcia

AbstractPurpose:Lung metastasis is responsible for nearly all deaths caused by osteosarcoma, the most common pediatric bone tumor. How malignant bone cells coerce the lung microenvironment to support metastatic growth is unclear. This study delineates how osteosarcoma cells educate the lung microenvironment during metastatic progression.