James Brenton

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Metabolic imaging distinguishes ovarian cancer subtypes and detects their early and variable responses to treatment - Oncogene

Dec 5, 2024 | nature.com | Susana Ros |Alan Wright |Ashley Sawle |James Brenton

AbstractHigh grade serous ovarian cancer displays two metabolic subtypes; a high OXPHOS subtype that shows increased expression of genes encoding electron transport chain components, increased oxygen consumption, and increased chemosensitivity, and a low OXPHOS subtype that exhibits glycolytic metabolism and is more drug resistant.

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