James I. MacRae

Jun 18, 2024 | hiv.gov | James I. MacRae

Content From: James Macrae, MA, MPP, Associate Administrator, Bureau of Primary Health Care, Health Resources and Services Administration, U.S. Department of Health and Human Services••3 min readTopicsThe Health Center Program, funded by the Health Resources and Services Administration’s (HRSA) Bureau of Primary Health Care (BPHC), plays a critical role in the efforts to end the HIV epidemic by providing comprehensive, accessible, and affordable health care to medically underserved populations.

Dec 6, 2023 | nature.com | Paul Driscoll |Jason Day |Alexander Morrell |James I. MacRae

AbstractMigration of T cells is essential for their ability to mount immune responses. Chemokine-induced T cell migration requires WNK1, a kinase that regulates ion influx into the cell. However, it is not known why ion entry is necessary for T cell movement. Here we show that signaling from the chemokine receptor CCR7 leads to activation of WNK1 and its downstream pathway at the leading edge of migrating CD4+ T cells, resulting in ion influx and water entry by osmosis.