Jamie Burgess

1 month ago | biorxiv.org | Karla Sanchez |Jamie Burgess |Qin Zheng |Uazman Alam

AbstractFibromyalgia syndrome (FMS) is characterized by elevated levels of immunoglobulin G (IgG), altered bowel habits, and increased pain sensitivity, suggesting immune dysregulation, but the exact mechanism remains unclear. Here, we found that FMS-IgG binds to mast cells in a MRGPRX2/b2-dependent manner, leading to mast cell recruitment and IL-6 secretion.