Jan-Savas Carstens

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Suppression of Ovarian Cancer Cell Proliferation is Associated with Upregulation of Cell-Matrix Adhesion Programs and Integrin-β4-Induced Cell Protection from Cisplatin.

Feb 15, 2025 | biorxiv.org | Sadaf Farsinejad |Daniel Centeno |Jan-Savas Carstens |Teagan Polotaye

AbstractThe role of extracellular matrix adhesion components in the modulation of the treatment sensitivity of ovarian cancer (OC) cells is not well understood. Analysis of ovarian cancer TCGA gene expression data sets revealed an inverse correlation between genes involved in cell-cycle progression and extracellular matrix interactions including laminin-binding receptor integrin 4, a major component of extracellular matrix adhesion.

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