Jan Wenzel

Oct 6, 2024 | nature.com | Xin Rui Lim |Mohammad M Abd-Alhaseeb |Michael Ippolito |Thomas Longden |Markus Schwaninger |Jan Wenzel

AbstractHyperemia in response to neural activity is essential for brain health. A hyperemic response delivers O2 and nutrients, clears metabolic waste, and concomitantly exposes cerebrovascular endothelial cells to hemodynamic forces. While neurovascular research has primarily centered on the front end of hyperemia—neuronal activity-to-vascular response—the mechanical consequences of hyperemia have gone largely unexplored.