Jane Frederick

Beaufort

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Articles

Chromatin reprogramming and bone regeneration in vitro and in vivo via the microtopography-induced constriction of cell nuclei - Nature Biomedical Engineering

Jun 12, 2023 | nature.com | Xinlong Wang |Vasundhara Agrawal |Yugang Liu |Priyam Patel |Emily M. Pujadas |Jane Frederick | +2 more

AbstractTopographical cues on cells can, through contact guidance, alter cellular plasticity and accelerate the regeneration of cultured tissue. Here we show how changes in the nuclear and cellular morphologies of human mesenchymal stromal cells induced by micropillar patterns via contact guidance influence the conformation of the cells’ chromatin and their osteogenic differentiation in vitro and in vivo.

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