Janusz Rak

Dec 3, 2024 | nature.com | Janusz Rak

Cancer cells often secrete extracellular vesicles (EVs), bubble-like structures thought to elicit pro-metastatic states. New work shows that colorectal cancers systemically export their genetic material attached to the surface of specific EVs. These DNA-carrying EVs are taken up by macrophages in the liver, activating anti-metastatic immune responses.

Aug 10, 2024 | nature.com | Janusz Rak |Jean-Claude Tardif |Matthieu Ruiz |Eric Boilard

AbstractLymphatic vessels are essential for preventing the accumulation of harmful components within peripheral tissues, including the artery wall. Various endogenous mechanisms maintain adequate lymphatic function throughout life, with platelets being essential for preserving lymphatic vessel integrity. However, since lymph lacks platelets, their impact on the lymphatic system has long been viewed as restricted to areas where lymphatics intersect with blood vessels.

Nov 15, 2023 | mdpi.com | Katarzyna Pietrucha-Urbanik |Janusz Rak

All articles published by MDPI are made immediately available worldwide under an open access license. No specialpermission is required to reuse all or part of the article published by MDPI, including figures and tables. Forarticles published under an open access Creative Common CC BY license, any part of the article may be reused withoutpermission provided that the original article is clearly cited. For more information, please refer tohttps://www.mdpi.com/openaccess.