Jared R. Coombs

Jan 23, 2024 | science.org | Jared R. Coombs |Yingying Wang |Leslie K. Ferrarelli |Huili Yao |Yu ZHANG |Ning Mu | +9 more

Research Article DEVELOPMENT Yingying Wang https://orcid.org/0000-0003-2124-2650, Huili Yao https://orcid.org/0009-0006-7669-3327, [...] , Yu Zhang, Ning Mu https://orcid.org/0000-0001-8057-3164, [...] , Tong Lu https://orcid.org/0000-0001-5283-0194, Zhiyuan Du, Yingdi Wu, Xiaopeng Li, Min Su, [...] , Ming Shao https://orcid.org/0000-0002-7484-2644, Xiaoyang Sun https://orcid.org/0000-0002-4014-1268, Ling Su https://orcid.org/0000-0001-7008-0550 [email protected], and Xiangguo Liu...

Jan 23, 2024 | science.org | Jared R. Coombs |Yingying Wang |Leslie K. Ferrarelli

AbstractYTHDC1 activates the DNA repair kinase ATR to suppress bleomycin-induced lung fibrosis. SIGN UP FOR THE SCIENCEADVISER NEWSLETTER The latest news, commentary, and research, free to your inbox daily Alveolar epithelial cells accumulate DNA damage and consequently undergo senescence in patients with idiopathic pulmonary fibrosis (IPF), a progressive lung disease for which there is no effective therapy.

Jan 23, 2024 | science.org | Jared R. Coombs |Yingying Wang |Leslie K. Ferrarelli |Alina Zamoshnikova |Caroline L. Holley |Madhavi P. Maddugoda | +9 more

Research ArticleIMMUNOLOGYJared R. Coombs https://orcid.org/0000-0002-1703-1247, Alina Zamoshnikova https://orcid.org/0000-0002-2904-7764, [...] , Caroline L. Holley https://orcid.org/0000-0002-2231-0136, Madhavi P. Maddugoda https://orcid.org/0000-0002-9508-3894, [...] , Daniel Eng Thiam Teo https://orcid.org/0000-0003-1422-5086, Camille Chauvin https://orcid.org/0000-0002-3121-6651, Lionel F Poulin, Nazarii Vitak, Connie M.

Jan 23, 2024 | sciencemag.org | Jared R. Coombs |Yingying Wang |Leslie K. Ferrarelli |Huili Yao

Published In Science SignalingVolume 17 | Issue 820January 2024Article versionsSubmission historyReceived: 10 January 2022Accepted: 4 January 2024PermissionsRequest permissions for this article. AcknowledgmentsWe thank Y. Zhao (CAS Center for Excellence in Molecular Cell Science) for providing GLI2, GLI3, and 8× GliBS luciferase reporter plasmids. We also thank Y. Guo and H. Yu (State Key Laboratory of Microbial Technology, Shandong University) and J. Shen and Q.

Jan 23, 2024 | sciencemag.org | Jared R. Coombs |Yingying Wang |Leslie K. Ferrarelli |Alina Zamoshnikova

Published In Science SignalingVolume 17 | Issue 820January 2024Article versionsSubmission historyReceived: 31 January 2021Accepted: 4 January 2024PermissionsRequest permissions for this article. AcknowledgmentsWe acknowledge the contribution from N. Matigian for statistical support received through the QCIF Biostatistics, University of Queensland, and thank K. Stacey for helpful technical discussions regarding the TOFIE technique she developed.