Jaroslaw Sedzicki

Feb 27, 2024 | nature.com | Jaroslaw Sedzicki |Dongchun Ni |Henning Stahlberg

AbstractThe synthesis of complex sugars is a key aspect of microbial biology. Cyclic β-1,2-glucan (CβG) is a circular polysaccharide critical for host interactions of many bacteria, including major pathogens of humans (Brucella) and plants (Agrobacterium). CβG is produced by the cyclic glucan synthase (Cgs), a multi-domain membrane protein. So far, its structure as well as the mechanism underlining the synthesis have not been clarified.