Jason Carlquist

Feb 18, 2024 | onlinelibrary.wiley.com | James Stock |Megan Melnyk |Sakima A. Smith |Jason Carlquist

1 INTRODUCTION Transvenous endomyocardial biopsy (EMB) is an invasive procedure that is frequently used in the definitive pathologic diagnosis of cardiac allograft rejection in patients with an orthotopic heart transplant (OHT).1-3 Recent advances in cell-free DNA and other noninvasive methods for detection of asymptomatic detection have reduced but not removed the need for EMB in the definitive diagnosis of OHT rejection, which occurs at a rate of approximately 12%–13% during the first year...