Jason Karpac

Nov 20, 2023 | nature.com | Xiaotong Li |Jason Karpac

AbstractNutrient availability is a major selective force in the evolution of metazoa, and thus plasticity in tissue function and morphology is shaped by adaptive responses to nutrient changes. Utilizing Drosophila, we reveal that distinct calibration of acyl-CoA metabolism, mediated by Acbp6 (Acyl-CoA binding-protein 6), is critical for nutrient-dependent tissue plasticity.

May 8, 2023 | nature.com | Jason Karpac

Gene–environment interactions have been found to shape ageing plasticity in the muscle tissue of migratory locusts through adaptive changes in lipid metabolic processes. There is notable heterogeneity in ageing and longevity among animals. Even within individuals of the same species, diversity in environment and ecology have a role in shaping differing rates of ageing — often defined as ageing plasticity1.