Jason L. Nomburg

Sep 23, 2024 | nature.com | Jason L. Nomburg |Erin Doherty |Nathan Price |Daniel Bellieny-Rabelo

Correction to: Nature https://doi.org/10.1038/s41586-024-07809-y Published online 26 August 2024In the version of the article initially published, in the “Similarity to non-viral proteins” section, the sentence originally reading “…the AlphaFold database, which contains more than 300,000 proteins from 21 organisms” has now been corrected to “the AlphaFold database, which contains more than 500,000 proteins from 48 organisms”.

Aug 26, 2024 | nature.com | Jason L. Nomburg |Erin Doherty |Nathan Price |Daniel Bellieny-Rabelo

AbstractThe rapid evolution of viruses generates proteins that are essential for infectivity and replication but with unknown functions, due to extreme sequence divergence1. Here, using a database of 67,715 newly predicted protein structures from 4,463 eukaryotic viral species, we found that 62% of viral proteins are structurally distinct and lack homologues in the AlphaFold database2,3.

Jan 23, 2024 | biorxiv.org | Jason L. Nomburg |Nathan Price |Jennifer Doudna

AbstractRapid virus evolution generates proteins essential to infectivity and replication but with unknown function due to extreme sequence divergence. Using a database of 67,715 newly predicted protein structures from 4,463 eukaryotic viral species, we found that 62% of viral proteins are evolutionarily young and lack homologs in the Alphafold database.