Jason S Wasserman

Mar 6, 2023 | biorxiv.org | Bulat Faezov |Kishan Patel |Alison M. Kurimchak |Jason S Wasserman

AbstractThe Ser/Thr protein phosphatase 2A (PP2A) is a highly conserved collection of heterotrimeric holoenzymes responsible for the dephosphorylation of many regulated phosphoproteins. Substrate recognition and the integration of regulatory cues are mediated by B regulatory subunits that are complexed to the catalytic subunit (C) by a scaffold protein (A). PP2A/B55 substrate recruitment was thought to be mediated by charge-charge interactions between the surface of B55α and its substrates.