Javier Leo
Subdirector at Redacción Medica
Subdirector de Desarrollo Digital de @redaccionmedica
Articles
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Aug 23, 2024 |
digitalcommons.library.tmc.edu | Andrew Hahn |Bilal Siddiqui |Javier Leo |Eleonora Dondossola
AbstractGiven the central role of the androgen receptor (AR) in prostate cancer cell biology, AR-targeted therapies have been the backbone of prostate cancer treatment for over 50 years. New data indicate that AR is expressed in additional cell types within the tumor microenvironment. Moreover, targeting AR for the treatment of prostate cancer has established side effects such as bone complications and an increased risk of developing cardiometabolic disease, indicating broader roles for AR.
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Aug 23, 2024 |
digitalcommons.library.tmc.edu | Javier Leo |Eleonora Dondossola |Kaitlin J. Basham |Nathaniel Wilson
The androgen receptor (AR) is one of the oldest therapeutic targets in oncology and continues to dominate the treatment landscape for advanced prostate cancer, where nearly all treatment regimens include some form of AR modulation. In this regard, AR remains the central driver of prostate cancer cell biology. Emerging preclinical and clinical data implicate key roles for AR in additional cancer types, thereby expanding the importance of this drug target beyond prostate cancer.
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May 14, 2023 |
biorxiv.org | Javier Leo
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