Jay Unruh

Jun 14, 2024 | elifesciences.org | Ruonan Zhao |Emma Moore |Madelaine Gogol |Jay Unruh

eLife assessment This fundamental study reports compelling findings that intermediate states exist in epithelial-mesenchymal transition (EMT) during natural development and differentiation of mammalian neural crest cells, similar to recent reports in cancer. The authors determined that there were at least two paths to delamination and migration - one that occurs during S-phase of cell cycle and another during G2/M phase, and that the process of delamination is not restricted to cell fate.

Oct 26, 2023 | biorxiv.org | Ruonan Zhao |Emma Moore |Madelaine Gogol |Jay Unruh

AbstractEpithelial to mesenchymal transition (EMT) is a cellular process that converts epithelial cells to mesenchymal cells with migratory potential in both developmental and pathological processes. Although originally considered a binary event, EMT in cancer progression involves intermediate states between a fully epithelial and a fully mesenchymal phenotype, which are characterized by distinct combinations of epithelial and mesenchymal markers.