Jean-Philippe Pin

Nov 27, 2024 | nature.com | Chanjuan Xu |Kun Xi |Robert B. Quast |Yi-Ru Liu |Yang Gao |Emmanuel Margeat | +3 more

AbstractThe structural basis for the allosteric interactions within G protein-coupled receptors (GPCRs) heterodimers remains largely unknown. The metabotropic glutamate (mGlu) receptors are complex dimeric GPCRs important for the fine tuning of many synapses. Heterodimeric mGlu receptors with specific allosteric properties have been identified in the brain.

Apr 24, 2024 | nature.com | Jean-Philippe Pin |Philippe Rondard |Ping Yi

AbstractG protein-coupled receptors naturally oscillate between inactive and active states, often resulting in receptor constitutive activity with important physiological consequences. Among the class C G protein-coupled receptors that typically sense amino-acids and their derivatives, the calcium sensing receptor (CaSR) tightly controls blood calcium levels. Its constitutive activity has not yet been studied.

Mar 4, 2024 | nature.com | Chanjuan Xu |Jean-Philippe Pin |Philippe Rondard

AbstractG protein-coupled receptors (GPCRs) constitute the largest family of membrane proteins and are important drug targets. The discovery of drugs targeting these receptors and their G protein signaling properties are based on assays mainly performed with modified receptors expressed in heterologous cells. However, GPCR responses may differ in their native environment.