Jean-Pierre de Villartay

Feb 4, 2024 | nature.com | Evgeniya V. Petrova |Matthias Fahrner |Jean-Pierre de Villartay |Claire Barbieux |Johann E. Gudjonsson |Florent Leturcq | +1 more

AbstractNetherton syndrome (NS) is a rare skin disease caused by loss-of-function mutations in the serine peptidase inhibitor Kazal type 5 (SPINK5) gene. Disease severity and the lack of efficacious treatments call for a better understanding of NS mechanisms. Here we describe a novel and viable, Spink5 conditional knock-out (cKO) mouse model, allowing to study NS progression.