Jeetain Mittal

2 weeks ago | biorxiv.org | Jiahui Wang |Arash Nikoubashman |Young Kim |Jeetain Mittal

AbstractThe morphology of biomolecular condensates plays a critical role in regulating intracellular organization and function by enabling both spatial and temporal control over biochemical processes. Recent studies have shown that small-molecule cosolutes can not only modulate phase separation but also influence condensate morphology. However, the mechanistic understanding of how small molecules regulate condensate structure remains limited.

1 month ago | cell.com | Tim M Gemeinhardt |Roshan M Regy |Tien Phan |Nanu Pal |Jyoti Sharma |Olga Senkovich | +13 more

Keywords sterile alpha motif oligomerization molecular dynamics simulations phase separation gene regulation Polycomb intrinsically disordered regions biomolecular condensates analytical ultracentrifugation biochemistry CRISPR Drosophila Introduction Biomolecular condensates and their emergent properties are central to the functional organization of cellular molecules,1,2 including chromatin and its regulatory proteins.3,4,5,6 These condensates form through multivalent interactions involving...