Jeffery D. Molkentin

Mar 21, 2024 | nature.com | Jeffery D. Molkentin

AbstractMitochondrial Ca2+ overload can mediate mitochondria-dependent cell death, a major contributor to several human diseases. Indeed, Duchenne muscular dystrophy (MD) is driven by dysfunctional Ca2+ influx across the sarcolemma that causes mitochondrial Ca2+ overload, organelle rupture, and muscle necrosis. The mitochondrial Ca2+ uniporter (MCU) complex is the primary characterized mechanism for acute mitochondrial Ca2+ uptake.

Dec 4, 2023 | cincinnatichildrens.org | Michael Gaies |Jeffery D. Molkentin |David Morales |Andrew Redington

Michael Gaies, MD, Named Executive Co-Director of Cincinnati Children’s Heart Institute Cincinnati Children’s is pleased to announce that Michael Gaies, MD, MPH, MS has been named executive co-director of the Heart Institute, effective immediately. Gaies has also been named division director of Pediatric Cardiology and Kindervelt Samuel Kaplan Chair in Cardiology. He joins current Heart Institute executive co-directors Jeffery Molkentin, PhD, and David Morales, MD.

Aug 25, 2023 | reachmd.com | Jeffery D. Molkentin

Ever since the Jerry Lewis telethons began in the 1960s, millions of people have become familiar with an otherwise rare disease called muscular dystrophy (MD). The medical world has learned much over the ensuing years, including that more than 30 closely related disorders exist that can produce the gradual muscle degeneration that steals a child’s ability to walk and eventually disrupts other organ functions. An estimated 250,000 people in the U.S. are living with a muscular dystrophy.