Jeffrey A. Mensah

Aug 30, 2024 | onlinelibrary.wiley.com | Kristina Johnson |Tia Freeman |Christopher Reilly |Jeffrey A. Mensah

The hyperthermia-induced seizure assay in Scn1aA1783V/WT mice mimics febrile seizures in clinical settings. Triple-drug therapy may be a valuable preclinical strategy for screening investigational compounds for DS. The study sought to enhance our understanding of drug–drug interactions of combination therapies in treating DS. The study designed a triple-drug paradigm that mimics clinical standards for identifying effective therapies.