Jeffrey M. McKenna

Mar 6, 2024 | nature.com | Angel Gonzalez-Valero |Jeffrey M. McKenna |James Wells |F. Dean Toste

AbstractMethods for selective covalent modification of amino acids on proteins can enable a diverse array of applications, spanning probes and modulators of protein function to proteomics1,2,3. Owing to their high nucleophilicity, cysteine and lysine residues are the most common points of attachment for protein bioconjugation chemistry through acid–base reactivity3,4.