Jella N. Freitag

Mar 13, 2024 | onlinelibrary.wiley.com | Iker Irisarri |Sophie de Vries |Amra Dhabalia Ashok |Jella N. Freitag

1 INTRODUCTION The diversification of protein families is one of the major drivers in the evolution of biological complexity. Cytochrome P450 (CYP450s or CYPs) is one of the largest protein families, with a current number of 443,000 proteins across the tree of life and particularly abundant in eukaryotes (Sezutsu et al., 2013; Richter et al., 2022).