Jennifer J. Tuscher

Nov 8, 2023 | elifesciences.org | Robert Phillips |Ethan Wan |Jennifer J. Tuscher |David Reid

eLife assessment This is an important study that uses chromatin accessibility as a measure to determine the impact of neuronal activity on the state of chromatin regulatory elements in striatal neurons. The authors provide convincing evidence of how Pdyn gene expression is highly dependent on a distal regulatory genomic region both at basal and upon neuronal activation in this particular system, a mechanism conserved as well in human neuronal cells.

Aug 21, 2023 | biorxiv.org | Robert Phillips |Ethan Wan |Jennifer J. Tuscher |David Reid

AbstractNeuronal and behavioral adaptations to novel stimuli are regulated by temporally dynamic waves of transcriptional activity, which shape neuronal function and guide enduring plasticity. Neuronal activation promotes expression of an immediate early gene (IEG) program comprised primarily of activity-dependent transcription factors, which are thought to regulate a second set of late response genes (LRGs).

Jun 5, 2023 | biorxiv.org | Robert Phillips |Ethan Wan |Jennifer J. Tuscher |David Reid

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